Maria Cristina Dechecchi

Maria Cristina Dechecchi si è laureata in Scienze Biologiche e successivamente si è specializzata in Biochimica e Chimica Clinica. Attualmente è Dirigente Biologo presso l’Azienda ospedaliera di Verona. Ha una lunga esperienza di diagnostica molecolare della fibrosi cistica e da molti anni conduce ricerche nel campo dell’infiammazione polmonare FC. Si è occupata di alcune molecole antinfiammatorie della famiglia degli iminozuccheri, che recentemente ha ottimizzato per l’applicazione terapeutica dell’infiammazione in fibrosi cistica.

• Dechecchi MC, Nicolis E, Bezzerri V, et al. MPB-07 reduces the inflammatory response to Pseudomonas aeruginosa in cystic fibrosisbronchial cells. Am J Respir Cell Mol Biol, 2007 May, 36(5):615-24.
• Dechecchi MC, Nicolis E, Norez C, et al. Anti-inflammatory effect of miglustat in bronchial epithelial cells. J Cyst Fibros, 2008 Nov, 7(6):555-65. doi: 10.1016/j.jcf.2008.06.002.
• Dechecchi MC, Nicolis E, Mazzi P, et al. Modulators of sphingolipid metabolism reduce lung inflammation. Am J Respir Cell Mol Biol, 2011 Oct, 45(4):825-33. doi: 10.1165/rcmb.2010-0457OC.
• Dechecchi MC et al. Pharmacological modulators of sphingolipid metabolism for the treatment of cystic fibrosis lung inflammation. Cystic Fibrosis INBS Book, 2011.
• Galli F, Battistoni A, Gambari R, et al., Oxidative stress and antioxidant therapy in cystic fibrosis. Biochim Biophys Acta. 2012 May;1822(5):690-713. doi: 10.1016/j.bbadis.2011.12.012.
• Bezzerri V, Avitabile C, Dechecchi MC, et al. Antibacterial and anti-inflammatory activity of a temporin B peptide analogue on an in vitro model of cystic fibrosis. J Pept Sci, 2014 Oct; 20(10):822-30. doi: 10.1002/psc.2674.
• Loberto N, Tebon M, Lampronti I, et al., GBA2-encoded β-glucosidase activity is involved in the inflammatory response to Pseudomonas aeruginosa. PLoS One. 2014 Aug 20;9(8):e104763. doi: 10.1371/journal.pone.0104763. eCollection 2014.
• Silvia Munari, Nicoletta Loberto, Massimo Aureli, et al., Neoglycoconjugates Derived from Deoxynojirimycin as Possible Therapeutic Agents for Cystic Fibrosis Lung Disease, by Modulation of the Sphingolipid Metabolism. JSM Genetics and Genomics, short communication, 2016.
• Chiricozzi E, Loberto N, Schiumarini D et al. Sphingolipids role in the regulation of inflammatory response: from leukocyte biology to bacterial infection. J Leukoc Biol. 2018 Jan 9. doi: 10.1002/JLB.3MR0717-269R. [Epub ahead of print].
• Lampronti I, Dechecchi MC, Rimessi A et al.  β-Sitosterol Reduces the Expression of Chemotactic Cytokine Genes in Cystic Fibrosis Bronchial Epithelial Cells. Front Pharmacol. 2017 May 12;8:236. doi: 10.3389/fphar.2017.00236. eCollection 2017.
• Purzner T, Purzner J, Buckstaff T, et al. Developmental phosphoproteomics identifies the kinase CK2 as a driver of Hedgehog signaling and a therapeutic target in medulloblastoma. Sci Signal. 2018 Sep 11;11(547). pii: eaau5147. doi: 10.1126/scisignal.aau5147.
• Lampronti I, Dechecchi MC, Rimessi A, Bezzerri V, Nicolis E, Guerrini A, Tacchini M, Tamanini A, Munari S, D’Aversa E, Santangelo A, Lippi G, Sacchetti G, Pinton P, Gambari R, Agostini M, Cabrini G. β-Sitosterol Reduces the Expression of Chemotactic Cytokine Genes in Cystic Fibrosis Bronchial Epithelial Cells. Front Pharmacol. 2017 May 12;8:236. doi: 10.3389/fphar.2017.00236. eCollection 2017.
• Maria De Fenza, Daniele D’Alonzo, Anna Esposito, et al. Exploring the Effect of Chirality on the Therapeutic Potential of N-alkyl-deoxyiminosugars: Anti-Inflammatory Response to Pseudomonas Aeruginosa Infections for Application in CF Lung Disease. Eur J Med Chem, 175, 63-71 2019 Aug 1